![]() ![]() ![]() Specifically, you will explore the role of glycan receptor binding in norovirus diversity and evolution. Although it is well-established that NoVs require specific glycans to infect host tissues and cells, the underlying mechanisms have yet to be fully elucidated.Īs a PhD student in position 7 of this project, you will focus on investigating the mechanisms of norovirus infections in humans. ![]() Notably, no therapy is currently available to treat or prevent NoV infections. While NoV infections are usually self-limiting in healthy individuals, they can lead to severe complications in immunocompromised individuals, young children, and the elderly. Norovirus is the leading cause of viral gastroenteritis and foodborne illnesses, which result in significant morbidity, mortality, and economic losses. Glycans play a crucial role in viral infections by facilitating norovirus attachment and entry. These aims will be achieved by bringing together 5 academic and 3 industrial leaders in the fields of glycoscience, glycovirology and norovirus, and relying on a multidisciplinary and interconnected approach. Going beyond the state-of-the-art, the overall aim of GlycoNoVi is training 10 researchers to address knowledge gaps on norovirus glycan interactions and investigate the exciting possibility of developing synthetic glycans as antiviral strategies to treat norovirus infection. ![]()
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